Description

Welcome to Humulin R U-500

Humulin R U-500 is an insulin that is used to control high blood sugar in adults and children with diabetes mellitus who need more than 200 units of insulin in a day.

Humulin R U-500 contains 5 times as much insulin in the same volume (500 units/mL) as Humulin R U-100 (100 units/mL).
It is not known if Humulin R U-500 is safe and effective when used in combination with other insulins or when used in an insulin pump.

Proven to lower A1C with the potential for fewer daily injections.1*

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Humulin R U-500 is highly concentrated and contains 5 times as much insulin in 1 mL as standard U-100 (100 units/mL) insulin.

Do not share your Humulin R U-500 KwikPen or U-500 insulin syringes with other people, even if the needle has been changed. You may give other people a serious infection or get a serious infection from them.

Meaningful results, simpler regimen*†

In a clinical study, U-500 was shown to lower A1C by an average of 1.1% in people who were not well controlled when taking more than 200 units of standard U-100 insulin a day.‡

U-500 is an insulin that is taken 2 or 3 times per day. Because it can be prescribed without other insulins, you may be able to reduce the number of insulins you take.

*Compared to standard U-100 insulin. Most patients will require 2 to 3 daily injections of U-500. U-500 KwikPen dials and doses the units you need, up to 300 units at a time.

†With U-500, you can inject up to 80% less liquid and still get the dose you need.

‡The purpose of the study was to compare the efficacy and safety of 2 dosing treatments (2 or 3 injections per day) of U-500 in adults with type 2 diabetes who were uncontrolled with high doses of standard U-100 insulin. The results between the 2 treatments were similar.

24-week, open-label, randomized trial to compare the efficacy and safety of 2 dosing regimens (TID, n=162 vs BID, n=163) for U-500 insulin replacing high dose U-100 insulin (>200 units per day) with or without oral antihyperglycemic drugs in adult patients with uncontrolled type 2 diabetes. These regimens were found to be equivalent for A1C reduction over 24 weeks, and both were efficacious.1

Study conducted with U-100 insulin syringes and Humulin R U-500 vials.

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  • Do NOT perform dose conversion when using the Humulin R U-500 KwikPen or U-500 insulin syringe.
  • Do not take Humulin R U-500 if your blood sugar is too low (hypoglycemia) or you are allergic to any of the ingredients in Humulin R U-500.

Humulin R U-500 is a concentrated insulin

U-500 is 5 times more concentrated than standard U-100 insulin. When insulin is concentrated, it takes less liquid per dose than standard U-100 insulin to help reduce your blood sugar levels.

With U-500, you can inject up to 80% less liquid and still get the dose you need. Reducing the amount of liquid may also reduce the number of times you have to inject in a day.* And because U-500 can be prescribed by itself, you may be able to reduce the number of insulins you take.

* Compared to U-100 insulin. Most patients will require 2 or 3 daily injections of U-500.

Here’s one way to think about it

Same number of units, 80% less liquid per dose.*

*Compared to standard U-100 insulin. Most patients will require 2 or 3 daily injections of U-500.

Please see Instructions for Use included with your pen or read the instructions online.

Two syringes are depicted, showing the different volume of liquid needed to inject an equal amount of insulin between Humulin R U-500 insulin and U-100 insulins. The U-500 dose is shown as being 80% less volume than the U-100 dose.Visual comparison of volume for illustrative purposes only.

About the U-500 KwikPen®

With the U-500 KwikPen, you may notice some differences:

  • Aqua color2
  • It holds 1500 units per pen (standard U-100 pens hold 300 units)3
  • It doses as much as 300 units at one time and dials in 5-unit increments (standard U-100 pens dial and dose in single-unit increments )3
  • You’ll receive 2 pens per pack

*Please see the Instructions for Use included with your pen.

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Tell your healthcare provider:

  • If you have liver, kidney, or heart problems or any other medical conditions.
  • If you are pregnant, plan to become pregnant, or are breast-feeding.
  • About all the medicines you take, including prescription (especially ones commonly called TZDs thiazolidinediones) and over-thecounter medicines, vitamins, and herbal supplements.